Resveratrol, sold in supplements, and rich in antioxidant effects has an ability to stave off the effects of aging including heart disease, cancer, and Alzheimer’s.
However, scientists found that the added influence on muscle regeneration could be either good or bad depending on the concentration used.
In lab tests, resveratrol showed that small doses encourage repair process in cells, but higher doses had a negative effect.
“Stronger muscles and the ability of the muscle to repair damage are important for a healthy lifestyle, especially in older age where muscle decline can have a series of implications for a reduction in our quality of life,” said lead researcher Dr. Hans Degens from Manchester Metropolitan University (MMU). “So we analysed if resveratrol was able to promote the repair of muscle and reduce oxidative stress where free radicals (destructive molecules) speed up the ageing process.”
The researchers conducted experiments in the laboratory using muscle cells, and tested the muscle regeneration cycle which starts when the muscle precursors called “satellite” cells get activated.
A low 10 micromolar dose of resveratrol stimulated satellite cell activation and migration, while concentrations higher of 40 to 60 micromolars stopped it, and even damaged the cells.
The results were published in journal Scientific Reports.