Researchers found that effects of high-fat diet show even in those people who are not obese, and suggest that people should avoid fatty foods to stay away from psychiatric disorders resulting from such a diet.
A diet with excessive fat levels produces changes in health and behavior by altering the mix of bacteria in the gut, also known as gut microbiome, researchers observed.
“This paper suggests that high-fat diets impair brain health, in part, by disrupting the symbiotic relationship between humans and the microorganisms that occupy our gastrointestinal tracks,” commented John Krystal, editor of Biological Psychiatry.
Human microbiome consists of trillions of microorganisms, many of which reside in the intestinal tract.
Scientists at Louisiana State University investigated whether a microbiome influenced by high-fat diet alters the behavior and cognition functions in the absence of obesity.
In the study, researchers used non-obese adult mice that were hosted and maintained a normal diet, but received gut microbiota from donor mice that were fed either a high-fat diet or control diet. Mice participant in the study were evaluated for changes in behavior and cognition.
Subjects who received microbiota from a fat-diet exhibited multiple disruptions in behavior, including increased anxiety, impaired memory, and repetitive behaviors. Additionally, the same subjects displayed multiple detrimental effects in the body, including increased intestinal permeability and markers of inflammation.
The findings were published in journal Biological Psychiatry.