“Aspirin resistance is an important predictor of severe stroke and large stroke size in patients taking aspirin before having a stroke,” said Mi Sun Oh, MD, from the department of neurology at the Hallym University College of Medicine in Seoul, South Korea.
Dr. Sun Oh, lead study author goes continues: “In patients at high risk for stroke with aspirin resistance, different anti-clotting drugs — such as clopidogrel (Plavix) — can be considered as alternatives to prevent another stroke or decrease stroke severity.”
Even though doctors may be able to determine which patients may develop resistance to aspirin and receive higher doses of aspirin when needed, it is important to do so before changes occur.
“Eventually we may be able to identify people who are likely to be resistant to aspirin and give them higher doses or different drugs to prevent blood clots. However, we need better ways to identify people with aspirin resistance before any changes can be made. For now, people who are taking low-dose aspirin to prevent blood clotting and stroke should continue to do so,” Oh said.
Dr. Ralph Sacco, Chairman of Neurology at University of Miami Miller School of Medicine added this research reveals the relationship between aspirin and stroke. He ventured the opinion that “One way aspirin works is to prevent platelets [particles that form clots in the blood] from clumping, and this could mean that clots that are released and block brain arteries are smaller and lead to smaller areas of brain injury.”
Dr. Sacco also added that “Although we do not routinely test for aspirin resistance, in the future era of targeted medicine we may improve the ability to assess whether someone is aspirin-resistant and choose medicines more accurately.”