Sign up to our newsletter
and receive exclusive information and discount coupons straight to your inbox

Top news by writer

Daniel Tomas
Tehnology Writer

HEALTH / The daily deal : a neck massager at an unbeatable price
As of this week, helpmeoutDOC has begun offering a series of massively discounted health items for sale. Today it is time to introduce our readers…
July 28, 2016 | 0 comments

Gabriel Rosoga
Medical and Health Writer

BEAUTY & SKIN CARE / Bee venom serums work miracles on skin
Bee venom, when used in small dosis, proves to be a very effective natural medicine, with extremely beneficial impact on the human organism, with particular…
September 8, 2016 | 1 comment

Ion Gireada
Science Writer

HEALTH / Reasons why your brain hears a ringing
Brain activity in people affected by tinnitus is very different from what happens when sound is detected in brains of healthy people, new research uncovered.…
April 27, 2015 | 0 comments

Ionut Popescu
Health and lifestyle writer

HEALTH / Brits oblivious to obesity leading to cancer
British population largely unware of link between obesity and cancer, finds new survey conducted by the organization Cancer Research UK. According to the survey, 75%…
September 9, 2016 | 0 comments

“Heart-on-a-chip” device improves drug toxicity test

by Ion Gireada on 10 March 2015
Health, Medical technology     |      heart cells,  heart on a chip,  pluripotent ste,  stem cells

A “heart-on-a-chip” device containing human cardiac cells similar to real organ will serve as a tool for testing medicines, new research unveils.

Researchers put together a network of cardiac muscle cells stored in an inch-long silicone device that models human heart tissue, and demonstrated the viability of the system as a drug-testing platform for cardiovascular medications.

The device is an important step forward in the development of accurate, faster methods for testing drug toxicity, researchers commented.

“Ultimately, these chips could replace the use of animals to screen drugs for safety and efficacy,” said professor Kevin Healy from the University of California, Berkeley.

Predicting human reactions to new drugs involves a high failure rate when nonhuman animal models are used.

“It takes about 5 billion pounds on average to develop a drug, and 60 per cent of that figure comes from upfront costs in the research and development phase. Using a well-designed model of a human organ could significantly cut the cost and time of bringing a new drug to market,” said Healy.

The current alternative involving the use of heart cells derived from human-induced pluripotent stem cells – adult stem cells that can be directed to become different types of tissue.

The researchers designed their cardiac microphysiological system, or heart-on-a-chip, so that its 3-D structure would be comparable to the geometry and spacing of connective tissue fiber in a human heart.

In the future, this setup could also allow researchers to monitor the removal of metabolic waste products from the cells.

“This system is not a simple cell culture where tissue is being bathed in a static bath of liquid,” said study lead author Anurag Mathur, a postdoctoral scholar in Healy’s lab and a California Institute for Regenerative Medicine fellow.

“Heart-on-a-chip” device improves drug toxicity test

facebook pinterest google+